Possible Interaction: Prednisolone and Vitamin D

“It was experimentally revealed that prednisolone reduces the phosphorus absorption in intestine at 25% and the treatment by 1,25-dihydroxy-vitamin D3 and 1 alpha-hydroxyvitamin D3 promotes the normalization of this process.”

“Conclusion: Prednisolone is less effective in the treatment of children with severe hypercalcaemia secondary to vitamin D intoxication and timely implementation of other treatment regimens should be considered.”

“ Prednisolone in combination with vitamin D3 may be effective in reducing APRIL serum levels.”

“ Prednisolone , however, is not the complete antimetabolite of vitamin D and further work is needed to discover the metabolic process where it competes with vitamin D, particularly with its newly discovered metabolites, 25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol.”

“The concurrent administration of prednisolone (10 mg orally/day) and vitamin D caused significant inhibition of the intestinal absorption of calcium and phosphorus in all children with rickets.”

“The results of our short term balance experiments suggested that prednisolone had a blocking or antagonising effect on the metabolic actions of vitamin D on intestine.”

“A combined therapy with prednisolone and 1α-vitamin D3 significantly increased bone strength, toughness, and stiffness compared with control bones.”

“ Prednisolone treatment also caused a decreased bone density that was prevented both with 1 alpha-hydroxyvitamin D2 and 1 alpha-hydroxyvitamin D3.”

“ Prednisolone treatment to vitamin D-deficient rats produced a significant decrease of plasma phosphorus and inhibited the hyperphosphatemic effect of all vitamin D derivatives.”

“The administration of prednisolone to rats on a vitamin D and calcium-deficient diet reduced the stimulating effect of both 1,25(OH)2D3 and SM upon intestinal calcium transport.”