Possible Interaction: Prednisolone and Calcium Supplement

“Cyclical etidronate and calcium increased lumbar spine bone density in patients established on prednisolone treatment over a two-year period but had no effect on femoral density.”

“Cumulative dose of prednisolone and calcium supplement were higher in osteoporotic group compared with normal group.”

“After initial symptomatic reduction of calcium levels by forced diuresis, calcium and creatinine levels were lowered by administration of 60 mg prednisolone daily.”

“In one severe case, treatment with prednisolone was associated with an alteration to negative calcium and magnesium balance, and faecal losses of calcium were particularly high.”

“The 1-hydroxylase activity (81.1 +/- 27.1 pg/mg tissue/20 min) of … did not differ from that of group A. However, the urinary excretion of calcium (ratio of calcium/creatinine) was increased (0.18 +/- 0.07 …. 0.07 +/- 0.03, P less than 0.01) by prednisolone ….”

“ PRED treatment inhibited bone formation by decreasing bone mineral density, and suppressing the expression of Runt-related transcription factor 2 and bone morphogenetic … activity of alkaline phosphatase, upregulating the expression of receptor activator of nuclear factor-κB ligand, and increasing the serum content of calcium , phosphorus and … in rats.”

“When a pharmacological dose of prednisolone was added to treatment, calcium in renal tissue increased to 0.305–3.083 mg.”

“Hydrocortisone and prednisolone inhibited the histamine release from isolated rat mast cells induced by antigen, the ionophore A23187, and compound 48/80 in the absence and in the presence of calcium.”

“ Prednisolone slowed body growth and lowered net calcium absorption, calcium retention , femoral calcium, and total body calcium.”

“Salt and prednisolone each depressed calcium retention independently and together produced an additive adverse effect on calcium balance.”