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Last Updated: 8 months ago

Possible Interaction: Prednisolone and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

ACTH and cortisol levels in the plasma of patients who were treated with PSL (PSL[+] group, n = 18) were lower than those in the plasma of patients who were treated without PSL (PSL[−] group, n = 29; P < 0.05 and P < 0.01, respectively).
Clinical neuropharmacology  •  2012  |  View Paper
Cumulative response to prednisolone and adrenocorticotropic hormone (if needed) was higher among treatment-naive patients (84%) than among patients with prior exposure to first-line treatment (51%), with P < 0.001.
Pediatric neurology  •  2019  |  View Paper
Mathematical modeling into discrete pulses of activity revealed that intravenous infusion of the synthetic mixed glucocorticoid/mineralocorticoid agonist prednisolone produced rapid inhibition of ACTH and cortisol pulsatility within 30 min in the morning and afternoon.
Prednisolone also inhibited ACTH and cortisol secretion in response to exogenous CRH stimulation, inferring rapid feedback inhibition at the anterior pituitary.
The Journal of Neuroscience  •  2010  |  View Paper
ACTH was significantly lowered after Pred and Pred-Sal vs. Pla from the start of exercise to the end of the experiment (p < 0.05).
International journal of sports medicine  •  2006  |  View Paper
ACTH basal level was … h after prednisolone withdrawal (1.7 +/- 0.4 pmol/L vs. control, 3.5 +/- 0.6, P less than 0.02), but the ACTH … to oCRH was not significantly different from control (peak 12.8 +/- 2.0 pmol/L vs. 13.5 +/- 12.1, respectively).
The Journal of clinical endocrinology and metabolism  •  1992  |  View Paper
Prednisolone treatment leads to diminution of ACTH and cortisol levels, elevation of glucose, insulin and C-peptide concentrations in plasma compared to prednisolone-untreated patients, producing insignificant effect on plasma levels of STH, vasopressin, aldosterone, area and creatinine.
Klinicheskaia meditsina  •  1990  |  View Paper
Elevated ACTH concentrations were suppressed by prednisolone (25%), dexamethasone (2% of the hydrocortisone dose) or by addition of cyproterone acetate (100 mg/m2/day).
Acta endocrinologica. Supplementum  •  1986  |  View Paper
Thus, patients receiving 10 or more mg of prednisolone daily (or the equivalent dose of other glucocorticoids) showed a significantly smaller plasma corticosteroid rise during the infusion of corticotropin than patients receiving 5 or 7.5 mg daily.
The Journal of clinical endocrinology and metabolism  •  1965  |  View Paper
Prednisolone , but not kirenol, downregulated plasma ACTH and GRα expression significantly (p<0.01).
Journal of ethnopharmacology  •  2011  |  View Paper
Plasma ACTH concentrations significantly decreased for 18 to 24 hours after prednisolone treatment in group-1 dogs.
American journal of veterinary research  •  1999  |  View Paper
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