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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Prednisolone
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“ ACTH and cortisol levels in the plasma of patients who were treated with PSL (PSL[+] group, n = 18) were lower than those in the plasma of patients who were treated without PSL (PSL[−] group, n = 29; P < 0.05 and P < 0.01, respectively).”
Low-Dose Glucocorticoid Therapy Complements the Pituitary-Adrenocortical System and Reduces Anxiety and Insomnia in Myasthenia Gravis Patients“Cumulative response to prednisolone and adrenocorticotropic hormone (if needed) was higher among treatment-naive patients (84%) than among patients with prior exposure to first-line treatment (51%), with P < 0.001.”
“Mathematical modeling into discrete pulses of activity revealed that intravenous infusion of the synthetic mixed glucocorticoid/mineralocorticoid agonist prednisolone produced rapid inhibition of ACTH and cortisol pulsatility within 30 min in the morning and afternoon.”
“ Prednisolone also inhibited ACTH and cortisol secretion in response to exogenous CRH stimulation, inferring rapid feedback inhibition at the anterior pituitary.”
“ ACTH was significantly lowered after Pred and Pred-Sal vs. Pla from the start of exercise to the end of the experiment (p < 0.05).”
“… ACTH basal level was … h after prednisolone withdrawal (1.7 +/- 0.4 pmol/L vs. control, 3.5 +/- 0.6, P less than 0.02), but the ACTH … to oCRH was not significantly different from control (peak 12.8 +/- 2.0 pmol/L vs. 13.5 +/- 12.1, respectively).”
“ Prednisolone treatment leads to diminution of ACTH and cortisol levels, elevation of glucose, insulin and C-peptide concentrations in plasma compared to prednisolone-untreated patients, producing insignificant effect on plasma levels of STH, vasopressin, aldosterone, area and creatinine.”
“Elevated ACTH concentrations were suppressed by prednisolone (25%), dexamethasone (2% of the hydrocortisone dose) or by addition of cyproterone acetate (100 mg/m2/day).”
“Thus, patients receiving 10 or more mg of prednisolone daily (or the equivalent dose of other glucocorticoids) showed a significantly smaller plasma corticosteroid rise during the infusion of corticotropin than patients receiving 5 or 7.5 mg daily.”
“ Prednisolone , but not kirenol, downregulated plasma ACTH and GRα expression significantly (p<0.01).”
Kirenol upregulates nuclear annexin-1 which interacts with NF-κB to attenuate synovial inflammation of collagen-induced arthritis in rats.“Plasma ACTH concentrations significantly decreased for 18 to 24 hours after prednisolone treatment in group-1 dogs.”
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