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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“A concentration (CONCopt) of oxymetazoline and prazosin was calculated from these curves that would optimally antagonize binding of [3H]yohimbine to high-affinity sites, minimally inhibiting low-affinity binding.”
“The percentages of [3H]yohimbine binding that were inhibited by the CONCopt of oxymetazoline and prazosin were determined in numerous brain regions.”
Characterization of subtypes of alpha-2 adrenoceptors in the human brain.“In the presence of prazosin plus yohimbine at the above-mentioned concentrations the maximum response to EFS was reduced to 47.6 +/- 6.7% (n = 11).”
“4 The competitive and surmountable nature of the antagonism of phenylephrine‐induced contractions by prazosin and yohimbine allowed calculation of antagonist dissociation constants.”
“ Prazosin and yohimbine produced a parallel rightward shift in the control curve for phenylephrine and clonidine, respectively.”
“Phentolamine, prazosin or a combination of prazosin and yohimbine caused an inhibition of the hypertensive effect of tyramine, but propranolol, atenolol and/or atropine had no effect.”
Cardiovascular effects of tyramine: adrenergic and cholinergic interactions.“The blocking effect of yohimbine was significantly higher than that of prazosin.”
“The alpha(…, prazosin (1 microm) …(2) antagonist, yohimbine (1 microm) inhibited maximal contraction to 100 microm 4-MTA by 45.0 +/- 6.7% and 53.5 +/- 7.1% of … respectively, whereas the 5-hydroxytryptamine (5-HT) antagonist, ketanserin (100 nm) had no effect on the 4-MTA-mediated contraction.”
“Combined administration of prazosin and yohimbine not only significantly elevated the synthesis and release of CGRP and arterial NGF content, but also completely normalized blood pressure.”
“These results were further supported by the fact that the pA2-value of prazosin , an alpha1-antagonist, was approximately 2 log units higher than that of yohimbine , an alpha2-antagonist.”
“SummaryHandling-induced convulsions in the quaking mouse can be blocked by: phenobarbital, pentobarbital or phenytoin; postsynaptic alpha-adrenoceptor … blockers (yohimbine, mianserine); catecholamine liberating agent (amphetamine); noradrenaline reuptake inhibitors (cocaine, imipramine, desipramine).Moreover, the protective effect of yohimbine …, prazosin or alpha-methylparatyrosine, and the protective … but not by alpha-methyltyrosine.”
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