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Last Updated: 8 months ago

Possible Interaction: Prazosin and Yohimbine



Research Papers that Mention the Interaction

A concentration (CONCopt) of oxymetazoline and prazosin was calculated from these curves that would optimally antagonize binding of [3H]yohimbine to high-affinity sites, minimally inhibiting low-affinity binding.
The percentages of [3H]yohimbine binding that were inhibited by the CONCopt of oxymetazoline and prazosin were determined in numerous brain regions.
The Journal of pharmacology and experimental therapeutics  •  1993  |  View Paper
In the presence of prazosin plus yohimbine at the above-mentioned concentrations the maximum response to EFS was reduced to 47.6 +/- 6.7% (n = 11).
Journal of vascular research  •  1992  |  View Paper
4 The competitive and surmountable nature of the antagonism of phenylephrine‐induced contractions by prazosin and yohimbine allowed calculation of antagonist dissociation constants.
British journal of pharmacology  •  1990  |  View Paper
Prazosin and yohimbine produced a parallel rightward shift in the control curve for phenylephrine and clonidine, respectively.
The Journal of pharmacology and experimental therapeutics  •  1989  |  View Paper
Phentolamine, prazosin or a combination of prazosin and yohimbine caused an inhibition of the hypertensive effect of tyramine, but propranolol, atenolol and/or atropine had no effect.
European journal of pharmacology  •  2008  |  View Paper
The blocking effect of yohimbine was significantly higher than that of prazosin.
Indian journal of experimental biology  •  2007  |  View Paper
The alpha(…, prazosin (1 microm) …(2) antagonist, yohimbine (1 microm) inhibited maximal contraction to 100 microm 4-MTA by 45.0 +/- 6.7% and 53.5 +/- 7.1% of … respectively, whereas the 5-hydroxytryptamine (5-HT) antagonist, ketanserin (100 nm) had no effect on the 4-MTA-mediated contraction.
Autonomic & autacoid pharmacology  •  2006  |  View Paper
Combined administration of prazosin and yohimbine not only significantly elevated the synthesis and release of CGRP and arterial NGF content, but also completely normalized blood pressure.
Journal of hypertension  •  2005  |  View Paper
These results were further supported by the fact that the pA2-value of prazosin , an alpha1-antagonist, was approximately 2 log units higher than that of yohimbine , an alpha2-antagonist.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
SummaryHandling-induced convulsions in the quaking mouse can be blocked by: phenobarbital, pentobarbital or phenytoin; postsynaptic alpha-adrenoceptor … blockers (yohimbine, mianserine); catecholamine liberating agent (amphetamine); noradrenaline reuptake inhibitors (cocaine, imipramine, desipramine).Moreover, the protective effect of yohimbine …, prazosin or alpha-methylparatyrosine, and the protective … but not by alpha-methyltyrosine.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
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