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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Prazosin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Consistent with the results of our in-vivo experiments, both metoprolol and prazosin significantly inhibited the NE-induced SR Ca2+ leak and SCR.”
Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice“The results indicate that α1-adrenoceptor-mediated vasoconstriction in the pithed normotensive rat, which is characterized by its sensitivity to blockade by prazosin and its relative insensitivity to antagonism by yohimbine or rauwolscine, can be subdivided into two distinct processes which are differentially influenced by blockade of calcium entry.”
“The responses to noradrenaline in calcium-containing media were competitively inhibited by the alpha 1-selective antagonist, prazosin (pA2:9.23), and the responses to noradrenaline in calcium-free media were abolished by 10 nM prazosin.”
“Two calcium …, and prazosin produced a … the calcium accumulation when given prior to induction of ischemia (except for the highest dose of nicardipine), while they were ineffective when given … of reperfusion, and the suppression was found to be closely correlated with the decrease in HRxLVP before induction of ischemia.”
“Pretreatment with the alpha-adrenergic blocking agents phentolamine or prazosin prevented the increase in total and intracellular calcium.”
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