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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Praziquantel
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ Praziquantel leads to increase Ca 2 + influx and disrupts Ca 2+ homeostasis in adult Schistosoma .”
Schistosoma mansoni sarco/endoplasmic reticulum Ca2+ ATPases (SERCA): role in reduced sensitivity to praziquantel“The mode of action of PZQ involves increasing the calcium uptake of the parasite, resulting in tegumental damage and death of the parasite.”
“The schistosomicidal activity of praziquantel (PZQ) is accompanied by a large influx of calcium into the worms, suggesting that this phenomenon could be the source of the observed muscular contraction, surface disruption and eventual death of the parasite.”
“ Praziquantel has a selective effect on the tegument of trematodes and increases permeability of calcium.”
“These results indicate that Ca 2 + may play an essential role in the contractile activity of the musculature caused by praziquantel , which is controlled to a certain degree by Mg 2+ .”
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