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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Praziquantel and Calcium Supplement

Research Papers that Mention the Interaction

While praziquantel is known to trigger calcium influx into schisostomes, followed by spastic paralysis of the worms and tegumental disruption, the mechanism of action of the drug is not completely understood.
Toxicology and applied pharmacology  •  2017  |  View Paper
The schistosomicidal activity of praziquantel (PZQ) is accompanied by a large influx of calcium into the worms, suggesting that this phenomenon could be the source of the observed muscular contraction, surface disruption and eventual death of the parasite.
Experimental parasitology  •  2008  |  View Paper
Praziquantel , the drug of choice against schistosomiasis, disrupts calcium (Ca2+) homeostasis in schistosomes via an unknown mechanism.
Parasitology  •  2003  |  View Paper
Praziquantel has a selective effect on the tegument of trematodes and increases permeability of calcium.
Veterinary journal  •  1997  |  View Paper
These results indicate that Ca 2+ may play an essential role in the contractile activity of the musculature caused by praziquantel , which is controlled to a certain degree by Mg 2+ .
Zhongguo yao li xue bao = Acta pharmacologica Sinica  •  1980  |  View Paper