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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Povidone and Stearic Acid

supplement:

Stearic Acid

Research Papers that Mention the Interaction

We found that stearic acid in combination with PVP or LAE as excipients led to higher loading of the active and inactive compounds in CE15 as compared with a PLGA microencapsulation and also sustained release of CE15 in a tunable manner.
Drug Delivery and Translational Research  •  2020  |  View Paper
Based on the observed solid-state interaction, a combination of stearic and povidone should be avoided for immediate release formulations.
Furthermore, repeated heating and cooling cycles of povidone and stearic acid mixtures in various proportions using differential scanning calorimetry (DSC) showed that recrystallization of stearic acid from its melt was strongly affected by the presence of increasing amounts of povidone.
International journal of pharmaceutics  •  2008  |  View Paper