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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“ Verapamil , 15.5 micrograms/mL, relaxed the potassium contraction by 100% and the thromboxane contraction by 75%.”
Pharmacological relaxation of the saphenous vein during harvesting for coronary artery bypass grafting.“The calcium channel antagonists, nifedipine, verapamil and diltiazem (0.01-10 microM), inhibited responses to high potassium , and the initial phase of shortening and lengthening responses to noradrenaline.”
“Voltage-dependent calcium channels were shown to be present by the ability of the calcium channel blocker, verapamil , to inhibit insulin release caused by an agent that depolarizes membranes, potassium.”
“The calcium antagonists verapamil (2.2 x 10(-7)-2.2 x 10(-5)M) and nifedipine (2.9 x 10(-8)-2.9 x 10(-6)M) relaxed both arteries and veins contracted by noradrenaline or potassium , and reduced the responses to these agents when added 15 min.”
“Addition of verapamil caused a further reduction of the response to potassium , but not of that to noradrenaline.”
“ Verapamil and nitroglycerin relaxed preparations contracted by potassium and noradrenaline, and, when added prior to stimulation, reduced the contractile responses to these agents.”
“The preparations were relaxed by verapamil and/or isoproterenol.1.The non-activated preparation of bovine artery has a basal tone corresponding to 15±1.7% of the maximum of developed tension.2.The contraction induced by potassium depolarization was largely prevented by 11.3 μg/ml of verapamil.”
Relaxation of coronary arteries by electro-mechanical decoupling or adrenergic stimulation“Native potassium channels: Verapamil suppressed the potassium currents in micro- and submicromolar concentrations.”
“The canines pretreated with verapamil had a significantly greater increase (24% +/- 8%) in potassium concentration than the control canines (14% +/- 6%) 15 min after succinylcholine administration.”
“Depolarization by potassium also resulted in DBH reduction which was reversed by the voltage dependent Ca++ channel blockers nifedipine and verapamil.”
“Further experiments demonstrated that verapamil also increased cell potassium levels in control oxygenated tubules incubated in normal calcium medium.”
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