Possible Interaction: Potassium and Tubocurarine

“The mechanism for this is unknown but it is probable that tubocurarine stabilises muscle cell membrane and thereby prevents potassium loss into the plasma.s Poulsen & Secher6 have demonstrated the peripheral neuromuscular blocking action of diethyl ether, an action similar to that of tubocurarine.”

“The ED50 of d-tubocurarine was found to fall as the potassium level was lowered by dietary restriction.”

“ Potassium concentration gradients between the intracellular and the extracellular compartments may be more important than cellular potassium depletion per se in affecting responses to neuromuscular blocking agents such as succinylcholine, d-tubocurarine , or pancuronium.”

“The rate at which potassium ions antagonized the neuromuscular block produced by tubocurarine has been examined in isolated rat diaphragm muscle preparations.”