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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Potassium
drug:
Trimethoprim
Research Papers that Mention the Interaction
“Compared with the control group, trimethoprim decreased potassium excretion by 572 nmol/min (CI, 299 to 845 nmol/min).”
“Figure 3 shows that 1 mmol/L of trimethoprim inhibited net potassium secretion by 59% (CI, 26% to 92%).”
Renal Mechanism of Trimethoprim-induced Hyperkalemia“CONCLUSIONS Tr methoprim in creases plasma pot assium co ncentration probably by reducing urinary potassium excretion.”
“ Trimethoprim , but not sulfamethoxazole, was found to inhibit potassium secretion when perfused into distal tubules.”
“In vivo, trimethoprim caused a > 50% reduction in potassium (K+) excretion due primarily to a fall in the [K+] in the lumen of the terminal CCD.”
Antikaliuretic action of trimethoprim is minimized by raising urine pH.
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