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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Potassium and Trimethoprim, Sulfamethoxazole Drug Combination

Research Papers that Mention the Interaction

The mean potassium concentration in the treatment group increased after trimethoprim-sulfamethoxazole therapy was initiated, and a statistically significant difference in the mean potassium concentrations in the treatment group and the control group was noted on days 4 and 5 of therapy (Figure 1).
Annals of Internal Medicine  •  1996  |  View Paper
Co-administration of cotrimoxazole with other drugs that can increase potassium levels, such as angiotensinconverting-enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs, alias sartans), can lead to severe hyperkalaemia with a risk of cardiac arrhythmia (1).
Prescrire international  •  2015  |  View Paper
Conclusions: Serum creatinine and potassium concentrations should be monitored in outpatients receiving high-dose TMP-SMX.
The Annals of pharmacotherapy  •  2013  |  View Paper
Trimethoprim-sulfamethoxazole was believed to inhibit distal tubule sodium reabsorption and potassium secretion.
Annals of Internal Medicine  •  1996  |  View Paper