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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Potassium
Research Papers that Mention the Interaction
“The mean potassium concentration in the treatment group increased after trimethoprim-sulfamethoxazole therapy was initiated, and a statistically significant difference in the mean potassium concentrations in the treatment group and the control group was noted on days 4 and 5 of therapy (Figure 1).”
Hyperkalemia in Hospitalized Patients Treated with Trimethoprim-Sulfamethoxazole“Co-administration of cotrimoxazole with other drugs that can increase potassium levels, such as angiotensinconverting-enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs, alias sartans), can lead to severe hyperkalaemia with a risk of cardiac arrhythmia (1).”
“Conclusions: Serum creatinine and potassium concentrations should be monitored in outpatients receiving high-dose TMP-SMX.”
“ Trimethoprim-sulfamethoxazole was believed to inhibit distal tubule sodium reabsorption and potassium secretion.”
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