Possible Interaction: Potassium and Triamterene

“Acetazolamide produced slight hypokalemia and provoked attacks of weakness whereas triamterene increased potassium levels significantly.”

“Baseline potassium exeretion did not increase when furosemide was given alone, but potassium excretion fell when 50 mg or 100 mg of triamterene was also given.”

“By inhibiting the epithelial sodium channel (ENaC) in the cortical collecting duct, triamterene reduces potassium secretion , thus reducing the risk of hypokalemia.”

“Patients given triamterene showed a rise in potassium levels in plasma and cells and in the sodium efflux rate constant.”

“ Triamterene not only enhances the natriuretic property of furosemide but also accentuates potassium conservation.”

“The triamterene induced increase of plasma potassium concentration may contribute to the antitoxic effect, however, the effect persisted after the decrease of plasma potassium concentration (by addition of NaHCO3) to pretreatment values.”

“Amiloride and triamterene alone inhibited distal tubular sodium reabsorption and potassium secretion , and, when given with one of the loop diuretics, suppressed both the kaliuresis and the increased acid and ammonium excretion induced by the latter agents.”

“ Potassium elimination decreased significantly when threshold triamterene dosages were added.”