Possible Interaction: Potassium and Tetrodotoxin

“Blockade of spontaneous electrical activity by tetrodotoxin prevented the diffuse expression of NAC1, and depolarization with high potassium concentrations induced diffuse cellular localization in non‐differentiating cells.”

“ Tetrodotoxin blocked the electrically evoked overflow and reduced the response to potassium.”

“Calcium channel currents were studied using barium as the charge carrier while potassium and sodium currents were suppressed with TEA and TTX , respectively.”

“ Elevated potassium (100 mM KCl) can stimulate protein output in the presence of TTX.”

“The normal developmental increase in both potassium and sodium currents is inhibited by the sodium channel blocker tetrodotoxin , suggesting that electrical activity normally stimulates the expression of both these currents.”

“It was shown that depolarization induced by the high concentration of potassium caused an increase in the intensity of biochemiluminescence from the rat hippocampal slice, and that suppression of neural activity by tetrodotoxin elicited a decrease of its luminescence.”

“Depolarization of neurons in the VLD culture revealed voltage‐dependent sodium, calcium, and potassium currents which were blocked with, respectively, tetrodotoxin (TTX), cobalt, and tetraethylammonium and 4‐aminopyridine.”

“Since depressed contractions will of themselves reduce coronary flow, PAF's action on flow was also investigated in hearts whose contractions were blocked by elevated potassium concentrations plus tetrodotoxin.”

“Massive cell death induced by chronic exposure to tetrodotoxin was totally prevented by concomitant addition of 25 mM potassium , though these explants were significantly thinner than controls due to a large decrease in neuropil.”

“The effects of RX 77368 and potassium alone (15 mM) on NA release from both spinal cord and brainstem slices were reduced to basal levels with tetrodotoxin (10−7M).”