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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Potassium
drug:
Substance P
Research Papers that Mention the Interaction
“ Substance P induced a significant relaxation in segments with intact endothelium pre-contracted by potassium or 5-hydroxytryptamine.”
Endothelium-dependent relaxation to substance P in human umbilical artery is mediated via prostanoid synthesis.“Whereas these renal ….5 nmol SP blocked the natriuretic response (aCSF value 3.9±0.8; SP value 0.7±0.3μmolmin−1, … value 48.9±5.8; SP value 14.5±4.0μlmin−1, P<0.01) and potassium (aCSF value 4.8±0.…) at 30min post‐injection.”
“PDBu at 1 nM or 1‐oleoyl‐2‐acetyl‐sn‐glycerol at 50 µM did not alter resting release of peptides, but augmented potassium‐ and capsaicin‐stimulated release of both SP and CGRP approximately twofold.”
“ Potassium evoked a concentration‐ and extracellular Ca2+‐dependent release of SP.”
“After exposure to SP , there was a loss and subsequent recovery of surface NK1-R. The loss was prevented by hypertonic sucrose and potassium depletion, inhibitors of clathrin-mediated endocytosis.”
Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor.“In large A-cells (approximately 65 microns in diameter) in which ATP has been shown to inhibit M-current, substance P (0.1-1 microM) also inhibited this potassium current without activating the sodium-potassium current.”
“Muscarine and SP also decreased a "leak" potassium current.”
“These results indicate that SP inhibits activation of a calcium‐dependent potassium conductance which contributes to both the slow after‐hyperpolarization and the resting membrane potential.”
“ Substance P increases the amplitude of the potassium contracture tonic component.”
“ Substance P depolarizes these cultured neurones by reducing an inwardly rectifying potassium conductance; this conductance has been found in several neuronal types6–9 and has similar properties to those of certain other cells10–13.”
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