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Last Updated: 8 months ago

Possible Interaction: Potassium and Spironolactone



Research Papers that Mention the Interaction

Conclusion: This study showed that spironolactone can reduce potassium requirements and prevent hypokalemia by reducing urinary potassium loss in neutropenic patients on AmB treatment.
Results: Patients receiving concomitant AmB and spironolactone had significantly higher plasma potassium levels than those receiving AmB alone (P=0.0027).
Those patients receiving AmB and spironolactone required significantly less potassium supplementation to maintain their plasma potassium within the normal range (P=0.022).
European Journal of Clinical Pharmacology  •  2001  |  View Paper
2 SC-23992 (50 mg) and spironolactone (125 mg) each significantly increased sodium excretion and the sodium : potassium (Na/K) ratio, and decreased potassium excretion, when compared with placebo.
British journal of clinical pharmacology  •  1975  |  View Paper
Between … whose potassium levels … spironolactone by all clinicians decreased from 41.4% to 38.5%, with a decrease from 48.9% to 41.0% among dermatologists and …% among internists but with an increase from 71.4% to 75.4% among advanced practice clinicians (ie, nurse practitioners and physician assistants).
JAMA dermatology  •  2021  |  View Paper
Treatment with spironolactone or potassium supplements alone significantly increased serum potassium concentration by … ± 0.35 mmol/l, respectively (both P < 0.05), and combined therapy with spironolactone … potassium increased serum potassium concentration by 0.69 ± 0.64 mmol/l (…) mutation sites identified in 42 Chinese GS patients are novel.
Clinical and Experimental Nephrology  •  2016  |  View Paper
Data showed that eplerenone and spironolactone are both associated with the occurrence of gynecomastia, mastodynia, and abnormal vaginal bleeding and in addition, they can increase natriuresis and cause renal retention of potassium ; furthermore, eplerenone may cause hyperkalemia and promote the onset of metabolic acidosis or hyponatremia.
International journal of cardiology  •  2015  |  View Paper
ACEI, ARBs, and spironolactone may cause slight increases in potassium even in anuric patients, requiring increased surveillance.
Seminars in dialysis  •  2013  |  View Paper
Potassium increased with spironolactone in non-AAs (4.29±0.5–4.55±0.49 mmol/L) but not in AAs (4.32±0.54–4.31±0.49 mmol/L; race by treatment interaction, P=0.03) during the first month and remained higher throughout the trial.
Circulation. Heart failure  •  2013  |  View Paper
On spironolactone 25 mg, potassium was reduced to 40 mEq daily.
Journal of clinical hypertension  •  2012  |  View Paper
Both agents produce dose‐dependent increases in potassium concentrations, although the effect with spironolactone appears to be greater when both agents are administered at recommended doses.
Clinical cardiology  •  2008  |  View Paper
The results suggest that spironolactone administration decreases the renal excretion of magnesium and potassium in an equivalent manner.
Klinische Wochenschrift  •  2005  |  View Paper
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