Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 8 months ago

Possible Interaction: Potassium and Somatostatin



Research Papers that Mention the Interaction

The potassium increment was not mediated by a reduction in blood pH. Somatostatin abolished the rise in glucagon concentration and simultaneously markedly inhibited the rise in potassium and glucose levels.
Diabetologia  •  2004  |  View Paper
Somatostatin , in addition to depressing insulin, produced a slight but significant (p < 0.01) increase in potassium (Δ max: 0.2–0.8 mmol/l: mean ± SEM, 0.4±0.1).
Diabetologia  •  2004  |  View Paper
Somatostatin decreases the renal plasma flow, glomerular filtration rate, osmotic and free water clearances, sodium and potassium excretion and the tubular reabsorption of phosphorus while urinary osmolality increases.
Orvosi hetilap  •  1991  |  View Paper
Potassium increment was potentiated by the addition of somatostatin , despite the abolition of insulin and C-peptide rises (potassium delta max: 0.56 +/- 0.10 mmol/l; p less than 0.05).
Mineral and electrolyte metabolism  •  1986  |  View Paper
We have previously demonstrated in fetal cerebrocortical cells, that somatostatin SS ) mRNA levels can be induced by depolarizing agents such as high potassium concentrations and veratridine (VTD), and that these effects are calcium dependent.
Brain Research  •  2000  |  View Paper
Somatostatin (SRIF) release and synthesis are affected by numerous agents, such as high concentrations of potassium that cause depolarization of cellular membrane.
The results indicate that chronic exposure to VTD or high potassium concentration increases immunoreactive somatostatin and augments synthesis of its high-molecular-weight forms.
Regulatory Peptides  •  1990  |  View Paper
Depolarizing concentrations of potassium (40 mM) added to medium after incubation in the presence or absence of glucose produced similar 4-fold biphasic stimulation of SRIF release , suggesting that tissue viability was unimpaired by short term glucopenia.
Endocrinology  •  1989  |  View Paper
Somatostatin activates an inwardly rectifying potassium conductance in AtT-20 clonal corticotrophs, a cell line derived from the mouse pituitary gland.
Brain Research  •  1988  |  View Paper
A high concentration of potassium (25 mEq/liter) induced a pronounced release of insulin and glucagon and a moderate release of somatostatin.
General and comparative endocrinology  •  1987  |  View Paper
In the presence of a normal calcium level (1.3 mM) an increase in potassium from 4.4-13.8 mM caused enhanced SS output (from 46 +/- 8 pg/ml to 74 +/- 10 pg/ml; 2 P less than 0.05).
Endocrinology  •  1985  |  View Paper
Show More