Possible Interaction: Potassium and Somatostatin

“The potassium increment was not mediated by a reduction in blood pH. Somatostatin abolished the rise in glucagon concentration and simultaneously markedly inhibited the rise in potassium and glucose levels.”

“ Somatostatin , in addition to depressing insulin, produced a slight but significant (p < 0.01) increase in potassium (Δ max: 0.2–0.8 mmol/l: mean ± SEM, 0.4±0.1).”

“ Somatostatin decreases the renal plasma flow, glomerular filtration rate, osmotic and free water clearances, sodium and potassium excretion and the tubular reabsorption of phosphorus while urinary osmolality increases.”

“ Potassium increment was potentiated by the addition of somatostatin , despite the abolition of insulin and C-peptide rises (potassium delta max: 0.56 +/- 0.10 mmol/l; p less than 0.05).”

“We have previously demonstrated in fetal cerebrocortical cells, that somatostatin SS ) mRNA levels can be induced by depolarizing agents such as high potassium concentrations and veratridine (VTD), and that these effects are calcium dependent.”

“ Somatostatin (SRIF) release and synthesis are affected by numerous agents, such as high concentrations of potassium that cause depolarization of cellular membrane.”

“The results indicate that chronic exposure to VTD or high potassium concentration increases immunoreactive somatostatin and augments synthesis of its high-molecular-weight forms.”

“Depolarizing concentrations of potassium (40 mM) added to medium after incubation in the presence or absence of glucose produced similar 4-fold biphasic stimulation of SRIF release , suggesting that tissue viability was unimpaired by short term glucopenia.”

“ Somatostatin activates an inwardly rectifying potassium conductance in AtT-20 clonal corticotrophs, a cell line derived from the mouse pituitary gland.”

“A high concentration of potassium (25 mEq/liter) induced a pronounced release of insulin and glucagon and a moderate release of somatostatin.”

“In the presence of a normal calcium level (1.3 mM) an increase in potassium from 4.4-13.8 mM caused enhanced SS output (from 46 +/- 8 pg/ml to 74 +/- 10 pg/ml; 2 P less than 0.05).”