Possible Interaction: Potassium and Sodium Chloride

“It is concluded that infusion of 7.5% NaCl in a clinical relevant dose increases plasma potassium and causes minor changes in the acid‐base balance in normovolaemic women.”

“Salt-sensitive" hypertension responds particularly well, perhaps, in part, because supplementation with potassium increases the urinary excretion of sodium chloride.”

“ Potassium feeding reduces the hypertension resulting from concomitant NaCl feeding.”

“It is also known that potassium itself reduces the rise in blood pressure caused by sodium chloride intake and reduces the increased sympathetic postural response which is seen in people on lowsodium diets [3].”

“These results indicate that potassium reduces the rise in blood pressure caused by sodium chloride and reduces the increased sympathetic postural response seen in people on a low sodium intake.”

“Substituting potassium and/or magnesium salts for sodium chloride (NaCl) may enhance the feasibility of salt restriction and lower blood pressure beyond the sodium reduction alone.”

“Well-controlled human studies subsequently showed that the BP-rising effect of extremely high NaCl intake can be blunted by potassium supplementation.”

“Moreover, we found that co-administration of an alkalinizing salt of potassium (potassium citrate) with NaCl prevented NaCl from increasing urinary calcium excretion and bone resorption, as occurred with NaCl administration alone.”

“Additional potassium prevents, in sodium-sensitive people and rats, the rise in BP caused by extra sodium chloride.”

“Fractional excretion of potassium was reduced in response to sodium chloride loading.”