Possible Interaction: Potassium and Sodium Bicarbonate

“of sodium bicarbonate was used in treatment the potassium requirements increased to 40 meq.”

“ Sodium bicarbonate is effective for treatment of hyperkalemia primarily by enhancing renal potassium elimination rather than by translocating potassium into cells.”

“Furthermore, a trend towards lower plasma aldosterone (291 to 204 ng/L, P = 0.07) and potassium (5.1 to 4.8 mmol/l, P = 0.06) was observed in patients receiving sodium bicarbonate.”

“Following one year treatment with oral sodium bicarbonate and potassium citrate, total skeletal calcium increased by 3-10% in five of the patients.”

“ sodium bicarbonate has recently been found to be ineffective in lowering plasma potassium within one hour.”

“Presumably, transcellular shift of potassium from the extracellular to intracellular compartment occurred during the administration of sodium bicarbonate.”

“After treatment with glucose, insulin, and sodium bicarbonate the potassium fell to 8 M Eq/L and it declined to 4 M Eq/L after an acute hemodialysis, with reversal of the EKG to normal.”

“administration of sodium bicarbonate resulted only in small and mostly insignificant increases in cell potassium concentrations and induced only minor alterations in the cell/tubule fluid potassium concentration gradient for all cell types analysed.”

“Increasing the potassium concentration in the PSS from 6 to 20 mM enhanced the maximal contractions in response to norepinephrine and methacholine in the bicarbonate-containing PSS, whereas in the bicarbonate-free PSS, the treatment decreased the contractions.”

“Fluid resuscitation, loop diuretic, and sodium bicarbonate treatment decreased his potassium.”