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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Potassium
drug:
Salicylic Acid
Research Papers that Mention the Interaction
“ SA concentrations higher than 100 micrograms/ml caused an immediate increase in urinary flow and in fractional excretion of sodium, potassium , chloride and calcium.”
Renal handling and effects of salicylic acid in the isolated perfused rat kidney.“ Potassium egress was markedly increased via a furosemide-insensitive pathway when salicylate was used to replace Cl-.”
“Under similar experimental conditions, physostigmine sulphate and Na salicylate , respectively, decrease the sensitivity of the membrane to potassium depolarization by about 30%.”
“ Salicylate administration also increased the rate of excretion of potassium so that its clearance often exceeded that of creatinine.”
“ Salicylate increased the permneability to potassium and decreased the permeability to chloride in a reversible, dose-dependent manner, producing a concomitant increase in membrane potential and a decrease in membrane resistance.”
“The chronic administration of both sodium salicylate and potassium salicylate to rats produces a significant decrease in the intracellular K+ ion concentration in the livers of these animals (Charnock, Opit & Hetzel, 1961).”
“If so, the inward movement of potassium should be decreased in the presence of salicylate and the outward movement unaltered or decreased as the intracellular concentration of potassium falls.”
“ Salicylate promotes loss of potassium from the muscle and diminishes the incorporation of amino-acids into protein, whereas insulin stimulates amino-acid incorporation and does not promote loss of potassium.”
Effect of “Nacton” in Patients with Duodenal Ulcer
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