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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Similarly, potassium decreased QTUc dispersion ( quinidine , 210+/-62 to 130+/-75 ms(1/2), P<.01; CHF, 132+/-68 to 84+/-35 ms(1/2), P=.07) and was without effect in the control subjects.”
Normalization of acquired QT prolongation in humans by intravenous potassium.“The resulting potassium current showed outward rectification under physiological conditions and slight inward rectification with symmetrical high-K+ solutions and could be inhibited by application of halothane or quinidine.”
“Hence, the electrophysiologic action of quinidine was nullified by a low potassium concentration in both groups of experiments.”
“Lowering potassium to 0.8 mEq./L., in the presence of the same concentration of quinidine , significantly increased the maximal rate of depolarization (+82.5%), the height of action potential (+8.5%) and resting potential (+9.9%).”
“Antiarrhythmic drugs … quinidine , disopyramide), class III (sotalol, amiodarone), class IV (calcium … blockers) used at the same time with potassium depleters diuretics or beta-blocking agents result in the inhibition of repolarization and the increased duration … activation potential with the risk of developing arrhythmia of the torsade de pointes types.”
“The potassium that moves through the Gardos pathway, on the other hand, can be accompanied by any permeant anion, and is inhibitable by quinidine or cetiedil.”
“It is concluded that quinidine reduces the membrane conductances for sodium, calcium, and potassium ions.”
“However, quinidine also blocks other potassium currents, such as Ito, and the degree of I(Kr) blockade with E4031 was probably greater than that with the same dose of quinidine.”
Effects of E4031 and quinidine on atrial and ventricular refractoriness in rabbits in vivo.“The potassium channel blockers quinidine and glibenclamide afforded some protection against hypoxic injury, although their effects on cellular potassium were equivocal.”
“ Quinidine (0.1‐1 mM) and tetraethylammonium ion (TEA) (10‐50 mM), blocked the potassium current in a dose‐dependent manner.”
“Volume regulatory release of potassium is impaired in 1 mmol/L quinidine , 1 mmol/L SITS and 5 mmol/L barium.”
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