Possible Interaction: Potassium and Propranolol

“Average change in potassium concentrations at peak exercise and recovery showed the Indians to have significantly higher increase in potassium levels with propranolol compared to the Malays (p = 0.038).”

“ Potassium levels returned to baseline more rapidly (compared with magnesium) in the placebo and atenolol groups (mean 10 minutes); however, recovery time was prolonged with propranolol (26 minutes) compared with placebo and atenolol (p less than 0.01).”

“Thus, the higher rise in potassium concentration during exercise with propranolol could only be explained by adrenergic blockade at the beta-2 receptor site.”

“Plasma potassium levels were increased during propranolol (P less than 0.05).”

“Both succinylcholine and a nonselective β-adrenergic blocker, propranolol , have the propensity to affect the transcellular redistribution of potassium which can result in hyperkalemia.”

“Ten allergic patients showed a greater potassium increment, as in normal subjects, when potassium was infused in the presence of propranolol.”

“In the diabetic group, propranolol , but not metoprolol, was associated with a deterioration in potassium tolerance.”

“In the nondiabetic group, both propranolol and metoprolol were associated with a 40% greater increase in potassium compared with exercise alone.”

“ Propranolol significantly increased plasma concentrations of uric acid and potassium , whereas labetalol significantly increased plasma concentrations of high‐density lipoproteins (HDL) and decreased the total cholesterol:HDL ratio; neither drug significantly changed renal function.”

“ Potassium delays the increase of plasma renin activity after furosemide and propranolol inhibits the furosemide-induced renin release, both without impairing aldosterone secretion.”

“We have previously reported in dogs after ventricular fibrillation that (1) potassium and calcium levels decrease and magnesium and glucose increase, (2) all values return to control levels by 3 hours, and (3) propranolol blocks the changes in potassium , magnesium, and glucose but not calcium.”