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Last Updated: 9 months ago

Possible Interaction: Potassium and Procaine

supplement:

Potassium

supplement:

Procaine

Research Papers that Mention the Interaction

A dose-related relaxation of the potassium contracture was observed with procaine.
Archives internationales de pharmacodynamie et de therapie  •  1984  |  View Paper
In normal Ringer solution, procaine suppressed potassium contracture which was composed of two components: an initial phasic component and a late tonic one.
Potassium contracture after perfusion with Ca-free solution was also suppressed by procaine.
The Japanese journal of physiology  •  1979  |  View Paper
2 Procaine (up to 20 Mm) caused relaxation when electrical activity was blocked by prior potassium depolarization.
British journal of pharmacology  •  1974  |  View Paper
Procaine (3.6 x 10-5 ∼ 3.6 x 10-4 M) suppressed the peak amplitudes of both sodium and potassium components of the end-plate current, the sodium current being slightly more affected than the potassium current.
The Journal of pharmacology and experimental therapeutics  •  1971  |  View Paper
The response to norepinephrine but not that to potassium is inhibited by procaine.
The Journal of pharmacology and experimental therapeutics  •  1968  |  View Paper
Potassium (80 mM)-induced tonic contractions were reduced by procaine 0.01–0.1% in both ureter and taenia.
Comparative biochemistry and physiology  •  1968  |  View Paper
Taylor (1959) found that procaine acts primarily by reducing the sodium and, to a lesser extent, the potassium conductances.
The Journal of general physiology  •  1966  |  View Paper
Changes in spike configuration and in the inward and outward currents of voltage-clamped axons agree in indicating that the increases in permeability to sodium and potassium ions during activity are depressed by procaine and cocaine and augmented by calcium.
The Journal of general physiology  •  1959  |  View Paper
Procaine (0.025–0.1%; pH 7.9) caused a reduction in the amount and rate of development of the early transient (sodium) and late steady state ( potassium ) currents which occur during a depolarizing voltage step applied to the excised, voltage clamped squid axon.
The American journal of physiology  •  1959  |  View Paper
Increased net uptake of sodium, loss of potassium , and concurrent increase in oxygen consumption are all effectively blocked by procaine.
The Journal of general physiology  •  1963  |  View Paper
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