Possible Interaction: Potassium and Procaine

“A dose-related relaxation of the potassium contracture was observed with procaine.”

“In normal Ringer solution, procaine suppressed potassium contracture which was composed of two components: an initial phasic component and a late tonic one.”

“ Potassium contracture after perfusion with Ca-free solution was also suppressed by procaine.”

“2 Procaine (up to 20 Mm) caused relaxation when electrical activity was blocked by prior potassium depolarization.”

“ Procaine (3.6 x 10-5 ∼ 3.6 x 10-4 M) suppressed the peak amplitudes of both sodium and potassium components of the end-plate current, the sodium current being slightly more affected than the potassium current.”

“The response to norepinephrine but not that to potassium is inhibited by procaine.”

“ Potassium (80 mM)-induced tonic contractions were reduced by procaine 0.01–0.1% in both ureter and taenia.”

“Taylor (1959) found that procaine acts primarily by reducing the sodium and, to a lesser extent, the potassium conductances.”

“Changes in spike configuration and in the inward and outward currents of voltage-clamped axons agree in indicating that the increases in permeability to sodium and potassium ions during activity are depressed by procaine and cocaine and augmented by calcium.”

“ Procaine (0.025–0.1%; pH 7.9) caused a reduction in the amount and rate of development of the early transient (sodium) and late steady state ( potassium ) currents which occur during a depolarizing voltage step applied to the excised, voltage clamped squid axon.”

“Increased net uptake of sodium, loss of potassium , and concurrent increase in oxygen consumption are all effectively blocked by procaine.”