Possible Interaction: Potassium and Potassium Chloride

“In both experiments the KCl load quickly increased plasma potassium and aldosterone concentrations and potassium and sodium excretion to a maximum by 2 h after the load, whereas the NaCl load had no such effect.”

“Once on the unit, she was put on Sando-K® (potassium supplement; potassium bicarbonate and potassium chloride ) but her potassium still tended to drop.”

“In both groups of patients, potassium chloride infusion augmented local plasma potassium concentrations.”

“After intravenous potassium chloride administration, maximum excretion of potassium (U,V) was significantly lower in sickle cell patients than in control subjects, and the percentage of potassium load excreted in 5 h was markedly reduced.”

“The oral administration of potassium chloride , 240 meq/day for four days, increased potassium to 3.0 meq/liter and increased iPGE to 8.0 μg/day.”

“The time course of changes in response to exposure to elevated levels of KCl shows an increase in internal concentrations of potassium and chlorine up to 2 h after exposure, followed by a decline.”

“In the rabbit colon model, potassium released from Slow-K and Micro-K Extencaps caused more irritation than from controlled-release GITS (KC1) (gastrointestinal therapeutic system KC1).”

“Rats receiving 300 mM KNO3, KHCO3, and KCl showed significantly increased plasma potassium levels and attenuation of stop-flow pressure responses 45-90 min after starting the potassium infusion compared with that observed in time controls and rats infused with 300 mM NaCl.”

“Oral administration of potassium chloride resulted in marked increases in plasma potassium concentrations in affected and unaffected foals, although hyperkalemia was associated with clinical signs of hyperkalemic periodic paralysis in the affected foals.”

“Contraction of the tissue at 60 versus 30 mM KCl or extending the interval in depolarizing solution from 15 to 60 min significantly enhanced the decline in tissue responsiveness to potassium.”