Possible Interaction: Potassium and Pinacidil

“The increases of K+ current by pinacidil were small (number of openings increased by 2%) when the recording pipette (and intracellular solution) … (50–300% increase in number of openings) when calcium in the intracellular solution was > 300 µmol/L. These observations suggest that pinacidil … potassium conductance, primarily … K+ channel.”

“ Pinacidil was found to inhibit aldosterone … and during stimulation with either potassium , angiotensin II (Ang II), or adrenocorticotropic hormone (/><0.001), with half maximal inhibition occurring at 10-5 M. As … the exclusion of trypan blue from cells, pinacidil did not inhibit secretion through injurious effects on glomerulosa cells.”

“It is concluded that pinacidil modifies the electrical activity of myocardial cells probably due to an increase in the potassium conductance although in high concentrations the compound might also reduce Ca2+ influx through the cell membrane, which would contribute to an obvious negative chronotropic action.”

“ Pinacidil is an antihypertensive agent that has been found to increase potassium conductance.”

“ Pinacidil (10(-5)-3 x 10(-5) M) in a non-competitive manner antagonized the contractions of isolated aorta elicited by noradrenaline (3 x 10(-…), adrenaline (10(-9)-3 x 10(-5) M), histamine (10(-6) 6 x 10(-4) M), serotonin (10(-8)-10(-4)M), and potassium (…).”