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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Potassium
drug:
Nicorandil
Research Papers that Mention the Interaction
“These data are consistent with attenuation of the anti-ischemic effects of this drug and suggest that the potassium channel-opening properties do not compensate for development of attenuation to the nitrate component of nicorandil.”
Attenuation of anti-ischemic efficacy during chronic therapy with nicorandil in patients with stable angina pectoris.“Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closure of voltage-gated calcium channels and finally vasodilatation.”
“In both preparations, nicorandil had only a slight inhibitory effect on the responses to potassium and Ca2+.”
Differential inhibitory effects of nicorandil, a new antiangina agent, on the contractile responses to alpha-1- and alpha-2-adrenoceptor agonists in isolated rabbit renal and femoral arteries.“It is likely that nicorandil inhibited depolarization through an increase in potassium conductance.”
“From these results it appears that nicorandil may increase the potassium conductances but not hyperpolarize the membrane potential because the background potassium conductance is little developed in the nodal cells.”
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