Possible Interaction: Potassium and Gentamicin

“These observations suggest that serum calcium, magnesium, and potassium should be monitored during gentamicin therapy.”

“Two patients developed severe hypomagnesemia, hypocalcemia, and hypokalemia as a result of renal wasting of magnesium and potassium shortly after being treated with large doses of gentamicin.”

“The results revealed that, GM injection induced marked nephrotoxicity as evidenced by significant increase in kidney functions, albumin and potassium (K+), with significant decrease in serum levels of total protein and sodium (Na+) as compared with negative control group.”

“We demonstrated that potassium depletion significantly increased gentamicin nephrotoxicity in Sprague-Dawley rats (100 mg X kg-1 X day-1).”

“ Potassium and magnesium deficiency have been reported as risk factors for experimental gentamicin nephrotoxicity.”

“The results show that potassium supplementation markedly lessens the severity of pathologic alterations induced by gentamicin.”

“Abnormalities of potassium and magnesium homeostasis have been reported following the use of gentamicin , and potassium depletion enhances gentamicin nephrotoxicity.”

“Plasma potassium fell in animals receiving high-dose gentamicin (3.8 +/- 0.02 mEq/L to 3.3 +/- 0.4, p less than 0.05) and reached the lowest values (2.7 and 2.9 mEq/L) just prior to death in two animals dying in uremia.”