Possible Interaction: Potassium and Desoxycorticosterone Acetate

“ Acute potassium loading with DOCA resulted in a lower increment in serum potassium than with spironolactone (P less than 0.01).”

“Although DOCA replacement modifies the distribution of potassium in the extracellular fluid and blunts the hyperkalemic effect of intravenous infusions of glucose, a rise in the insulin level is required for the usual hypokalemic response to intravenously administered glucose.”

“This suggests that doca must have more widespread action than just the'regulation of sodium and potassium balance, which in these patients was not grossly upset so far as the chemical investigations show.”

“After desoxycorticosterone-21-acetate injection , lowering of clearances of both sodium and potassium has been noticed and it may prove that kidney mechanisms responsible for potassium ion regulation show functional immaturity.”

“It is concluded that DOCA has differential effects on renal and gastrointestinal handling of electrolytes and that DOCA may induce an intracellular shift of potassium in pigs.”

“When potassium depletion is induced in rats administering desoxycorticosterone acetate instead of restricting potassium in the diet, the droplet accumulation in medullary cells is reduced, despite the similar degree and duration of potassium depletion.”