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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Potassium Citrate
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ Potassium citrate caused a decrease in urinary calcium and a significant increase in urinary citrate that resulted in a significant decrease in the urinary saturation of calcium oxalate.”
Alkali action on the urinary crystallization of calcium salts: contrasting responses to sodium citrate and potassium citrate.“During potassium citrate therapy, urinary calcium significantly declined from 154 +/- 47 mg/day to 99 +/- 23 mg/day (P less than 0.01) and urinary citrate rose from 398 +/- 119 mg/day to 856 +/- 103 mg/day (P less than 0.001).”
“ Urinary calcium excretion decreased by a mean of 60 mg/day on potassium citrate therapy —a nearly 30 % decrease in urine calcium excretion.”
“Net calcium balance was significantly improved in participants taking potassium citrate 90 mmol/d compared to placebo (142 ± 80 mg/d on 90 mmol/d versus −80 ± 54 mg/d on placebo; p = 0.02).”
“Another trial reported 391 mg (21 meq) Mg daily as a mixed salt, Mg potassium citrate , reduced calcium stone recurrence by 90%, similar to potassium citrate, but with better gastrointestinal tolerance.”
“Long term treatment (… who formed calcium stones … PSC in a single evening dose of 3.75 or 5.0 g (n = 55) gave a stone free rate of 75 … 5.0 or 7.5 g were given in two or three doses (n = 17).(ABSTRACT TRUNCATED AT 400 WORDS)”
“ Potassium citrate appears to reduce calcium excretion in both types of hypercalciuric type I renal tubular acidosis.(ABSTRACT TRUNCATED AT 400 WORDS)”
“ Potassium citrate caused a significant decrease in urinary calcium.”
“ Potassium citrate caused a significant increase in urinary pH and urinary citrate, and a decrease in urinary calcium.”
“ Calcium stone formation can be prevented by the use of different drugs with different mechanisms of action (thiazide diuretics, allopurinol, and potassium citrate ), but there is no ideal drug that is both risk free and well tolerated.”
Recent advances in managing and understanding nephrolithiasis/nephrocalcinosis
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