Possible Interaction: Potassium Chloride and Taurine

“The depolarizing agent KCl promoted an increase in aspartate, glutamate, and taurine release from hypoglycemic synaptosomes.”

“In small DRG sensory neurons from diabetic rats, recovery of intracellular Ca2+ concentration ([Ca2+]i) in response to KCl was slowed and 73% corrected by taurine.”

“We recently showed that chronic taurine supplementation is associated with attenuation of contractile responses of rat aorta to norepinephrine and potassium chloride.”

“Although the basal rate of taurine release was 35.3 pmol/min/mg protein of synaptosomes (second highest releasing rate), the 2-min stimulation with KCl (30 mM) evoked only a 1.3-fold increase in release of taurine (47.3 pmol/min/mg).”

“It is concluded that taurine is likely to coparticipate with KCl as an osmoeffector during RVD in Carassius proximal renal tubule cells.”

“Hypoosmotic media and 65 mM KCl stimulated TAU release, and the release was well correlated with the increase of cell volume.”

“Release of the neurotransmitter amino acids aspartate, glutamate, glycine, and gamma-aminobutyric acid (GABA) and the possible neurotransmitter taurine were dramatically increased by administration of 100 mM KCl.”

“Although basal release of these amino acids was not affected, taurine inhibited KCl (30 mM)-evoked overflow of Asp, Glu and GABA in a concentration-dependent manner with potencies (IC50) of 1 microM, 0.8 microM and 5 nM, respectively.”

“Basal release of Asp, Glu, HCA, Tau and GABA, but not of Gly, was significantly stimulated (p < 0.05) by KCl in all age groups.”

“e) Exposure of type‐1 or type‐2 astrocyte cultures to 50 mM KCl (replacing an equimolar concentration of NaCl) enhanced the release of taurine > glutamate > aspartate.”