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“From these observations, it is concluded that at low concentrations procaine acts … muscarinic receptors in the guinea-pig taenia caecum while high concentrations of procaine may depress the …, substance P and KCl by inhibiting the Ca-induced Ca release from the … by reducing the transmembrane Ca influx during depolarization.”
Naunyn-Schmiedeberg's Archives of Pharmacology • 2004 | View Paper
“3 Procaine , 0.5–10 mM, relaxed the sustained contractions induced by 65.4 mM KCl and 10−6 m noradrenaline in the aorta, and by 45.4 mM KCl, 10−6 m carbachol and 10−6 m histamine in the taenia.”