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“ Hesperetin and diosmetin, but not hesperidin and diosmin, dose-dependently (10-100µM) and reversibly inhibited acetylcholine (1µM) and KCl (80mM) induced contractile activity.”
European journal of pharmacology • 2016 | View Paper
“ Hesperetin (0.1 mM) significantly reversed the inhibitory effects of NA (1 μM) and high KCl (60 mM) on cyclic nucleotide (cAMP and cGMP) production in cultured rat aortic myocytes.”
“ Hesperetin concentration-dependently relaxed the isometric contractions induced by noradrenaline (NA, 1 μM) or by a high extracellular KCl concentration (60 mM) in intact rat isolated thoracic aorta rings.”