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Last Updated: 8 months ago

Possible Interaction: Potassium Chloride and Genistein

Research Papers that Mention the Interaction

In addition, genistein , resveratrol and 17beta-estradiol also could reduce the contractile responses of ACh and KCl , and shift their cumulative concentration-response curves rightward.
World journal of gastroenterology  •  2008  |  View Paper
Both U46619 (30 nM) and KCl (50 mM) increased MLC20 phosphorylation levels, which were inhibited by genistein and daidzein.
Furthermore, both genistein and daidzein decreased the amount of GTP RhoA activated by either U46619 or KCl.
The cumulative additions of U46619 or KCl increased vascular tension in a concentration-dependent manner, which were inhibited by pretreatment with genistein or daidzein.
Journal of Pharmacology and Experimental Therapeutics  •  2008  |  View Paper
Genistein concentration-dependently relaxed histamine (30 microM)-, carbachol (0.2 microM)-, KCl (30 mM)- and leukotriene D4 (10 nM)-induced precontractions and inhibited cumulative histamine- and carbachol-induced contractions in a non-competitive manner.
Planta medica  •  2007  |  View Paper
Gen (50 microM) also inhibited by 60% the [Ca(2+)](i) response to 50 mM KCl , indicating a direct interaction with voltage-sensitive, L-type Ca(2+) entry channels.
American journal of physiology. Renal physiology  •  2004  |  View Paper
In addition, genistein could reduce the contractile responses of NA, KCl and CaCl2, and shift their cumulative concentration-response curves rightward. (
Acta pharmacologica Sinica  •  2004  |  View Paper
Genistein further reduced Ca(2+) influx in response to KCl in the presence of nitrendipine, omega-conotoxin GVIA and omega-agatoxin IVA, simultaneously.
Our results suggest that genistein inhibits glutamate release and Ca(2+) influx in response to KCl independently of tyrosine kinase inhibition, and that tyrosine kinases and phosphatases are not key regulators of glutamate release in hippocampal nerve terminals.
We found that lavendustin A and herbimycin A did … glutamate release stimulated by 15 mM KCl, but genistein , also a broad range inhibitor of tyrosine kinases … inhibit the intracellular Ca(2+) concentration response to KCl and, concomitantly, decreased glutamate release evoked by … same stimulus, in a dose-dependent manner.
Neurochemistry International  •  2003  |  View Paper
At 100 microM genistein also inhibited the contractile effects of PdBu and KCl.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie  •  1998  |  View Paper
Genistein , but not tyrphostin A23 or diadzein (30 microM), attenuated significantly the contraction induced by KCl (p < 0.05).
Journal of neurosurgery  •  1998  |  View Paper
Genistein (20 microM), kaempferol (10 microM), quercetin (15 microM), verapamil (70 nM), nifedipine (10 nM) and forskolin (0.5 microM) inhibited the concentration-response curve to CaCl2 in medium supplemented with 33, 60 or 90 mM of KCl.
Genistein (IC50: 20.2 +/- 1.0 microM, n = 11), kaempferol (IC50: 10.1 +/- 0.8 microM, n = 8) and quercetin (IC50: 13.2 +/- 0.5 microM, n = 8) relaxed the tonic contraction induced by KCl (60 mM) in a concentration-dependent way.
However, the inhibitory effect of genistein on CaCl2-induced contraction was inversely related to the concentration of KCl in the medium.
General pharmacology  •  1997  |  View Paper