Possible Interaction: Potassium Bicarbonate and Calcium Supplement

“For all 10 subjects, KHCO3 administration reduced urinary Ca excretion from control by -0.9 +/- 0.7 mmol/day, P less than 0.001.”

“The administration of 60 mmol/d of KHCO3 to healthy adults reduced urinary calcium excretion by 0.9 mmol/d and caused calcium balance to become equivalently more positive.”

“ Urinary calcium declined significantly in both KHCO3 groups versus placebo (p < 0.001, adjusted for baseline urinary calcium, gender, and changes in urine creatinine and calcium intake).”

“In this meta-analysis, potassium bicarbonate and potassium citrate lowered urinary calcium and acid excretion and reduced the excretion of the bone resorption marker NTX.”

“Seminal work by Sebastian et al (… that the administration of base as potassium bicarbonate resulted in … decrease in urinary calcium and phosphorus excretion and an improvement in overall calcium balance, which was accompanied by a … urinary excretion of hydroxyproline (bone resorption) and an increase in serum osteocalcin (bone formation).”

“Results During the administration of potassium bicarbonate , the calcium and phosphorus balance became less negative or more positive -- that is, less was excreted in comparision with the amount inges...”

“A recent study of postmenopausal women has shown that the administration of 60-120 mmol potassium bicarbonate can neutralize net acid excretion and significantly lower urinary calcium ( Ca).”

“Compared with controls, K supplementation as KCl accentuated Ca excretion, whereas potassium bicarbonate or malate reduced Mg and Ca excretion and alkalinised urine pH (up to 8).”

“ KHCO3 significantly reduced UNTX, UCa , and serum P1NP but did not affect UN, serum IGF-1, or IGFBP3 levels compared with placebo over 84 days.”