Possible Interaction: Potassium and Aspartate

“Perfusion with artificial extracellular fluid containing 45 mM potassium produced a significant increase in aspartate and glutamate efflux.”

“Stimulation of the nucleus tractus solitarii with 35 mM potassium in vitro significantly increased extracellular concentrations of aspartate and glutamate.”

“Depolarization induced by the high potassium medium (40 mmol/L) enhanced the release of glutamate and aspartate from superfused rat striatum, whereas the efflux of glutamine remained unchanged.”

“In cerebellar granule cells, exposure to potassium resulted in a large (sixfold) and prompt release of D‐[3H]aspartate , largely calcium‐dependent.”

“Sodium ([Na+]o greater … [Na+]i gradients, and potassium ([K+]o less than [K+]i) or proton ([H+]o less … [H+]i) gradients can independently energize the Na+-dependent accumulation of L-aspartate above equilibrium levels, suggesting that Na+ and L-… cotransport occurs with concomitant K+ or H+ antiport.”

“In both CN and CX, potassium (5-55 mM) produced a concentration-dependent increase in the release of Asp , Glu, Gly, and GABA in the presence of extracellular Ca2+.”

“The uptake of d‐[3H]‐aspartate was found to be stimulated at high potassium in both glutamatergic neurons (98%) and in astrocytes (70%).”

“In the presence of aspartate in higher concentrations the absorption of both magnesium and potassium is inhibited to a certain degree.”

“Glutamate, aspartate and high potassium concentrations increase the rate of loss of potassium.”

“ Aspartate uptake at pH 8 in the absence of glucose is markedly greater in potassium than in sodium phosphate buffers; the effect of K+ is smaller in the presence of glucose and KCl is less effective than potassium phosphate.”