Possible Interaction: Potassium and Adrenocorticotropic Hormone

“ ACTH also enhanced potassium excretion but this was less obvious for cortisol.”

“These results indicate that potassium , independent of sodium and angiotensin, can regulate basal aldosterone secretion and sensitize the adrenal response to the aldosterone stimulatory properties of ACTH.”

“These results …) acute potassium loading causes a … the plasma ACTH level and increased levels of adrenocortical hormones may be produced by increased ACTH secretion, and (2) it may be considered … of the increased level of plasma aldosterone following acute potassium loading may arise from increased ACTH secretion in EH.”

“Clinical deterioration in patients on corticotrophin is associated with a fall of more than 20% in the intracellular potassium concentration, suggesting that all myasthenics so treated should be given potassium supplementation.”

“ ACTH induces retention of water and sodium, and transient retention of potassium.”

“Insulin, adrenaline, ACTH , and glucagon lower potassium levels in the rabbit.”

“ Adrenocorticotrophin at 100 and 500 micrograms/kg per day increased plasma sodium and decreased plasma potassium concentrations.”

“It was found that potassium stimulates the growth and the steroidogenic capacity of the zona fasciculata presumably by enhancing the trophic effects of ACTH.”

“It is well known that an increased potassium concentration stimulates the release of ACTH from pituitary cells in a calcium-dependent fashion10.”

“Incubation of rat adenohypophyses in a high concentration of potassium increases adrenocorticotropic hormone release.”