Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 8 months ago

Possible Interaction: Polyunsaturated Fatty Acids and Vitamin C

Research Papers that Mention the Interaction

Supplementation with vitamins C + E resulted in decreased OS and increased fluidity and PUFA proportion in the membrane, both of which positively modulate (Na,K)-ATPase activity, accounting for the blood pressure reduction.
Clinical and experimental hypertension  •  2014  |  View Paper
However, combination therapy with PUFA and vitamins C and E reduced the incidence of POAF by 68% (OR: 0.32; 95%CI: 0.17-0.60; P=0.0005; I(2)=38%).
Heart, lung & circulation  •  2014  |  View Paper
At a concentration of 10 mmol/1 ascorbic acid totally inhibits oxidative break-down of polyunsaturated fatty acids by radicals originating from hydrogen peroxide.
Free radical research communications  •  1985  |  View Paper
A correlation was found between excess consumption of fat, saturated fatty acids, cholesterol, sugar, deficiency in the diet of polyunsaturated fatty acids and vitamin C to the coronary heart disease prevalence.
Voprosy pitaniia  •  1984  |  View Paper
A combination of ω-3 PUFA and AA treatment confers an additive effect in suppressing lipid peroxidation and improving myocardial function.
ω-3 PUFA and AA combined have lower MDA and 4-HNE modified proteins than alone (p < 0.05).
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2020  |  View Paper
Vitamin C significantly reduced the % of PUFA and increased the % of saturated fatty acid (SFA) in the liver lipid.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology  •  2001  |  View Paper
Ascorbic acid treatment increases the content of polyunsaturated fatty acids in the lung considerably, i.e. the pulmonary membrane fluidity decreases significantly in response to ascorbic acid.
General pharmacology  •  1986  |  View Paper