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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Polyunsaturated Fatty Acids
drug:
Triiodothyronine
Research Papers that Mention the Interaction
“The triiodothyronine (T3) declined more (P less than .05) following the HF diet than the HP diet (baseline 198 micrograms/dl, HP 138, HF 113).”
Effect of low-carbohydrate diets high in either fat or protein on thyroid function, plasma insulin, glucose, and triglycerides in healthy young adults.“Total monounsaturated fatty acid and polyunsaturated fatty acid content increased (P < 0.05) in group T3 by 14.15 and 37.44%, respectively.”
Dietary supplementation of Butyrivibrio fibrisolvens alters fatty acids of milk and rumen fluid in lactating goats.“High-fat diets polyunsaturated fatty acids ) inhibited the extra thyroidal conversion of T4 to T3 in both stocks.”
“These data support the hypothesis that polyunsaturated fats uniquely suppress the gene expression of lipogenic enzymes by functioning as competitive inhibitors of T3 action, possibly at the nuclear receptor level.”
“To clarify what molecular events occur in this phenomenon, we investigated the glycerophospholipid and fatty acid (…-treated (4 °C) tadpoles with or without 5 nM 3,3′,5-triiodothyronine (T3).ResultsExposure to T3 … polyunsaturation of FAs in the glycerophospholipids, and increased plasma … FA chain elongase genes (elovl3 and elovl5).”
Cold temperature blocks thyroid hormone-induced changes in lipid and energy metabolism in the liver of Lithobates catesbeianus tadpoles
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