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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Polyunsaturated Fatty Acids
drug:
Steroids
Research Papers that Mention the Interaction
“Thus, numerous studies have demonstrated that fatty acids, particularly the polyunsaturated fatty acids , modulate positively or negatively many steps of the action of various steroids and many enzymes involved in the transduction of membrane-triggered signals. (”
Biological role of alpha-fetoprotein in the endocrinological field: data and hypotheses.“ Steroid hormones are thought to modulate PUFA synthesis in humans but whether they regulate PUFA status in brain and/or in neural membranes is unknown.”
“We conclude that steroids have differential effects on PUFA synthesis and that their mode of action could involve the modulation of the Delta5-desaturase mRNA expression in neuroblastoma cells.”
“Lately, much research has been done on the modulation of the binding of steroid hormones to their receptors by polyunsaturated fatty acids (PUFAs), which could interfere with the steroid hormone's message.”
“During cholesterol balance studies performed in eight patients, the feeding of polyunsaturated fats , as compared with saturated fats, caused an increased excretion of endogenous neutral steroids, acidic steroids , or both in most patients.”
“Furthermore, omega-6 and omega-3 polyunsaturated fatty acids are reported to alter follicular growth, steroid synthesis and prostaglandin metabolism in the ovary and endometrium, respectively.”
Dietary fat supplementation and the consequences for oocyte and embryo quality: hype or significant benefit for dairy cow reproduction?“However, dietary PUFAs may influence synthesis of both prostaglandins and steroid hormones.”
“Complementary multivariate and univariate data analysis identified that glycerolipids (mono-, di-, and triacylglycerides), saturated and mono/polyunsaturated fatty acids , primary fatty amides, glycerophospholipids (phosphatidylcholines, phosphatidylethanolamines), sphingolipids (ceramides, sphingomyelins), N-acylethanolamines and sterol lipids (cholesteryl esters, steroids ) were significantly increased in the CSF of PD compared to the control group.”
Alteration in the Cerebrospinal Fluid Lipidome in Parkinson’s Disease: A Post-Mortem Pilot Study“Also, PUFA provide the precursors for prostaglandin synthesis and can modulate the expression patterns of many key enzymes involved in both prostaglandin and steroid metabolism.”
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