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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Polyunsaturated Fatty Acids and Phosphatidylinositol 4,5-Diphosphate

Research Papers that Mention the Interaction

However, depletion of phosphatidylinositol 4,5-bisphosphate due to overexpression of the p110alpha subunit was significantly reduced by treating the yeast cells with the various PUFA.
Biotechnology journal  •  2009  |  View Paper
Collectively, these data demonstrate that n-3 PUFA , such as DHA, alter PtdIns(4,5)P2 in CD4+ T-cells, thereby suppressing the recruitment of WASP to the immunological synapse, and impairing actin remodelling in CD4+ T-cells.
Since PtdIns(4,5)P2 resides in raft domains and DHA can alter the size of rafts, we hypothesized that PtdIns(4,5)P2 and downstream actin remodelling are perturbed by the incorporation of n-3 PUFA into membranes, resulting in suppressed T-cell activation.
The Biochemical journal  •  2012  |  View Paper