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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Polyunsaturated Fatty Acids
supplement:
Phosphatidylinositol 4,5-Diphosphate
Research Papers that Mention the Interaction
“However, depletion of phosphatidylinositol 4,5-bisphosphate due to overexpression of the p110alpha subunit was significantly reduced by treating the yeast cells with the various PUFA.”
Polyunsaturated fatty acids inhibit PI3K activity in a yeast-based model system.“Collectively, these data demonstrate that n-3 PUFA , such as DHA, alter PtdIns(4,5)P2 in CD4+ T-cells, thereby suppressing the recruitment of WASP to the immunological synapse, and impairing actin remodelling in CD4+ T-cells.”
“Since PtdIns(4,5)P2 resides in raft domains and DHA can alter the size of rafts, we hypothesized that PtdIns(4,5)P2 and downstream actin remodelling are perturbed by the incorporation of n-3 PUFA into membranes, resulting in suppressed T-cell activation.”
n-3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activation.
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