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Last Updated: 2 years ago

Possible Interaction: Polyunsaturated Fatty Acids and Linolenic Acid

Research Papers that Mention the Interaction

ALA supplementation, or increased consumption of ALA-rich foodstuffs, combined with reduced omega-6 (n6) PUFAs intake, could improve the n3/n6 ratio and improve cardiometabolic and lipid profile.
Nutrients  •  2020  |  View Paper
The … PUFA and … ɤ-linolenic acid (0.00 ± 0.00 to 0.13 ± 0.11, p < 0.001), which was undetectable in all groups before the treatments; (4) … with n-3 fatty acids alone or in combination with GLA exerted significant clinical benefits and certain changes in disease activity.
Nutrients  •  2017  |  View Paper
…:Alpha-linolenic acid content, expressed as the mean (standard deviation) total human … significantly higher after diet supplementation with omega-3 PUFAs , with values of 2.2% (0.7%) (MR), 1.3% (0.5%) (R), 1.…%) (M), and 0.8% (0.3%) (O at D30) (p < .003 for each comparison).
Journal of human lactation : official journal of International Lactation Consultant Association  •  2017  |  View Paper
Consumption of both α-linolenic acid (RR, 0.73; 95% CI, 0.59-0.89; P = .003 for trend) and marine ω-3 PUFAs (RR, 0.84; 95% CI, 0.65-1.08; P = .03 for trend) contributed to this inverse association.
JAMA neurology  •  2014  |  View Paper
BackgroundDietary supplementation with botanical oils that contain n-6 and n-3 eighteen carbon chain (… γ linolenic acid (GLA, 18:3n-6), stearidonic acid (SDA, 18:4n-3) and α linolenic acid (ALA, 18:3n-… shown to impact PUFA metabolism, alter inflammatory processes including …) metabolism and improve inflammatory disorders.
Lipids in Health and Disease  •  2013  |  View Paper
Dietary total fat, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid PUFA ), LA, total &ohgr; 6 polyunsaturated fatty acid (T&ohgr;6PUFA), and &agr;-linolenic acid ( ALA ) intake positively predicted serum LA concentration.
Journal of pediatric gastroenterology and nutrition  •  2012  |  View Paper
Also, the presence of 22-carbon polyunsaturated fatty acids shows an inhibitory effect on the initial conversion steps of linoleic and α-linolenic acids.
Advances in lipid research  •  1989  |  View Paper
When … polyunsaturated fatty acid content of the microsomal membrane fraction was … by supplementing the culture medium with linolenic or docosahexaenoic acids (n‐3 polyunsaturated fatty acids) or arachidonic acid (n‐6 polyunsaturated fatty acid), the K′m of the high‐affinity choline transport system was reduced by 40–60%.
Journal of neurochemistry  •  1982  |  View Paper
ALA strongly affects the conversion of both hepatic n-3 and n-6 LC-PUFA.
Animal : an international journal of animal bioscience  •  2012  |  View Paper
Fifteen weeks of dietary n-3 PUFA deprivation increases coefficients of conversion of circulating α-linolenic acid (α-LNA; 18:3n-3) to docosahexaenoic acid (DHA; 22:6n-3) in rat liver but not brain.
Journal of Lipid Research  •  2007  |  View Paper
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