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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Polyunsaturated Fatty Acids
supplement:
Linolenic Acid
Research Papers that Mention the Interaction
“ ALA supplementation, or increased consumption of ALA-rich foodstuffs, combined with reduced omega-6 (n6) PUFAs intake, could improve the n3/n6 ratio and improve cardiometabolic and lipid profile.”
Beyond Fish Oil Supplementation: The Effects of Alternative Plant Sources of Omega-3 Polyunsaturated Fatty Acids upon Lipid Indexes and Cardiometabolic Biomarkers—An Overview“The … PUFA and … ɤ-linolenic acid (0.00 ± 0.00 to 0.13 ± 0.11, p < 0.001), which was undetectable in all groups before the treatments; (4) … with n-3 fatty acids alone or in combination with GLA exerted significant clinical benefits and certain changes in disease activity.”
“…:Alpha-linolenic acid content, expressed as the mean (standard deviation) total human … significantly higher after diet supplementation with omega-3 PUFAs , with values of 2.2% (0.7%) (MR), 1.3% (0.5%) (R), 1.…%) (M), and 0.8% (0.3%) (O at D30) (p < .003 for each comparison).”
“Consumption of both α-linolenic acid (RR, 0.73; 95% CI, 0.59-0.89; P = .003 for trend) and marine ω-3 PUFAs (RR, 0.84; 95% CI, 0.65-1.08; P = .03 for trend) contributed to this inverse association.”
“BackgroundDietary supplementation with botanical oils that contain n-6 and n-3 eighteen carbon chain (… γ linolenic acid (GLA, 18:3n-6), stearidonic acid (SDA, 18:4n-3) and α linolenic acid (ALA, 18:3n-… shown to impact PUFA metabolism, alter inflammatory processes including …) metabolism and improve inflammatory disorders.”
“Dietary total fat, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid PUFA ), LA, total &ohgr; 6 polyunsaturated fatty acid (T&ohgr;6PUFA), and &agr;-linolenic acid ( ALA ) intake positively predicted serum LA concentration.”
“Also, the presence of 22-carbon polyunsaturated fatty acids shows an inhibitory effect on the initial conversion steps of linoleic and α-linolenic acids.”
“When … polyunsaturated fatty acid content of the microsomal membrane fraction was … by supplementing the culture medium with linolenic or docosahexaenoic acids (n‐3 polyunsaturated fatty acids) or arachidonic acid (n‐6 polyunsaturated fatty acid), the K′m of the high‐affinity choline transport system was reduced by 40–60%.”
“ ALA strongly affects the conversion of both hepatic n-3 and n-6 LC-PUFA.”
Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs.“Fifteen weeks of dietary n-3 PUFA deprivation increases coefficients of conversion of circulating α-linolenic acid (α-LNA; 18:3n-3) to docosahexaenoic acid (DHA; 22:6n-3) in rat liver but not brain.”
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