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“These preliminary results suggest that diets high in polyunsaturated fat, particularly linoleic acid, impair absorption and utilization of iron and zinc, and possibly magnesium, and may reduce endurance performance.”
International journal of sport nutrition and exercise metabolism • 2001 | View Paper
“Ferroptosis is a recently characterized cell death phenotype resulting from iron catalyzed peroxidation of polyunsaturated fatty acid (PUFA) phospholipids.”
“Compared to controls, the FE group showed significant down-regulation of several n3 polyunsaturated fatty acids ( PUFAs ), including 20:5n3, 22:5n3, and 22:6n3 within the phosphatidylcholine and phosphatidylethanolamine lipid classes.”
“The administration of iron induces liver oxidative stress and depletion of long-chain polyunsaturated fatty acids (LCPUFAs), n-6/n-3 LCPUFA ratio enhancement and fat accumulation, which may be prevented by antioxidant-rich extra virgin olive oil (AR-EVOO) supplementation.”
Prostaglandins, leukotrienes, and essential fatty acids • 2020 | View Paper
“Alcohol, polyunsaturated fatty acids and iron feeding produced an increase in serum levels of iron , serum glutamate pyruvate transaminase and decrease in serum proteins.”
“The addition of iron led to increased MDA production in normal as well as in transformed cells, and to simultaneous consumption of polyunsaturated fatty acids ( PUFA ) and α-tocopherol.”
“Both ultraviolet radiations and iron ions induced a significant decrease in the content of polyunsaturated fatty acids , carotenes and vitamin E together with a large formation of lipid peroxidation products.”