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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Polyunsaturated Fatty Acids
drug:
Interleukin-10
Research Papers that Mention the Interaction
“Interferon-γ (pro-inflammatory) significantly decreased and interleukin-10 (anti-inflammatory) significantly increased in n-3 PUFAs.”
Anti-Inflammatory Potential of n-3 Polyunsaturated Fatty Acids Enriched Hen Eggs Consumption in Improving Microvascular Endothelial Function of Healthy Individuals—Clinical Trial“Pre-treatment of THP-1 cells, with either n-3 PUFA at 25 or 100 μM significantly reduced IL-6, IL-10 , and IL-12 secretion while DHA, but not EPA, reduced TNF-α response to LPS.”
“Conclusions: Supplementation with ω‐3 PUFAs can modulate the inflammatory response in rat AP, decreasing levels of TNF‐&agr;, IL‐6, IL‐1&bgr;, and IL‐17 but increasing levels of IL‐10.”
Omega‐3 Fatty Acids Reduce Inflammation in Rat Apical Periodontitis“Quantitative RT-PCR of representative … confirmed that n-3 PUFA consumption was associated with … of CD80, CTLA-4, IL-10 , IL-18, CCL-5, CXCR3, IL-6, TNF-α and osteopontin mRNAs in kidney and/… spleens as compared to mice fed n-6 PUFA or n-9 MUFA diets.”
“Associated with this deduction, n-3 PUFA significantly decreased the proportion of TCRalphabeta+CD8alpha+CD8beta- cells and IEL-derived TNF-alpha, IFN-gamma, IL-4 and IL-10.”
“N-3 PUFA enriched diet further increased interleukin-10 and 8-hydroxy-2′-deoxyguanosine levels.”
N-3 PUFA Prevent Oxidative Stress in a Rat Model of Beta-Amyloid-Induced Toxicity“CONCLUSIONS n-3 PU As co nsumption alters IgG N-glycan traits and IL- 10 in healthy individuals, and total plasma protein N-glycan traits in CV patients, by shifting them toward less inflammatory N-glycosylation profile.”
“It is concluded that IFN-γ, IL-4 and IL-10 may differentially regulate macrophage activation via effects on the metabolism of polyunsaturated fatty acids.”
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