Possible Interaction: Polyunsaturated Fatty Acids and Gamma-Linolenic Acid

“… PUFA … GLA (group II) increased ɤ-linolenic acid (0.00 ± 0.00 to 0.13 ± 0.11, p < 0.001), which was undetectable in all groups …: Daily supplementation with n-3 fatty acids alone or in combination with GLA exerted significant clinical benefits and certain changes in disease activity.”

“BackgroundDietary supplementation with botanical oils that contain n-6 and … chain (18C)-PUFA such as γ linolenic acid GLA , 18:3n-6), stearidonic acid (SDA, 18:4n-3) and … (ALA, 18:3n-3) have been shown to impact PUFA metabolism, alter inflammatory processes including …) metabolism and improve inflammatory disorders.”

“Supplementation with 20 microM GLA for 24 h led to a 230 and 22% increase in glioma and astrocyte PUFA content, respectively, such that both supplemented cell types contained similar levels of PUFA.”

“ GLA and LA supplementation increased the total polyunsaturated fatty acid ( PUFA ) content of the cells indicating increased oxidative potential.”

“According to locally weighted regression model, we observed obvious negative correlation between levels of five n-6 PUFAs (linoleic acid, γ-linolenic acid , eicosadienoic acid, dihomo-γ-linolenic acid and arachidonicacid) and DR.”

“Results: … with polyunsaturated fatty acid supplementation: α-linolenic acid (mean difference [MD] = −3.34, 95% confidence … acid (MD = −4.08, 95% CI = −8.97 to 0.82), γ-linolenic acid (MD = −2.23, 95% CI = −7.20 to 2.74), … = −4.05, 95% CI = −8.07 to −0.03).”