Possible Interaction: Polyunsaturated Fatty Acids and Doxorubicin Hydrochloride

“Certain physical and functional properties of the membrane are modified when the polyunsaturated fatty acid content is increased, and the cells become more sensitive to hyperthermia or treatment with doxorubicin.”

“We observed that PUFAs (especially arachidonic acid, AA) and BDNF (brain-derived neurotrophic factor) protect against the cytotoxic actions of alloxan, streptozotocin, benzo(a)pyrene (BP) and doxorubicin.”

“Our data showed that ω-3 PUFAs supplementation significantly mitigated the behavioral changes induced by DOX.”

“Single ω-3 PUFA treatment significantly enhanced antitumor activity of DOX associated with intensified tumoral oxidative stress and enhanced tumoral DOX concentration while not potentiating cardiac dysfunction or increasing cardiac oxidative stress.”

“Thus, dietary supplementation with n-3 PUFA attenuated doxorubicin-induced cardiac dysfunction, an effect that might be associated with recovery from an imbalance of the cytokine network.”

“As the latter decreased, CE accumulated massively 9 weeks after starting doxorubicin treatment, 20:4n-6 becoming their major PUFA.”

“ ADR treatment decreased the polyunsaturated fatty acids C22:6 n‐3 and C20:4 n‐6 in rat liver mitochondria.”

“Enrichment with polyunsaturated fatty acids resulted in a marked increase in sensitivity to adriamycin as compared to enrichment with monounsaturated fatty acids.”