Possible Interaction: Polyunsaturated Fatty Acids and Conjugated Linoleic Acid

“It is likely that perturbation of PUFA metabolism by CLA will have an impact on eicosanoid formation and metabolism, closely linked to the biological activities attributed to CLA.”

“Feeding mono- and polyunsaturated fatty acids increased tissue 18:1(trans-11) and CLA , which is a favorable change in regard to current human dietary guidelines.”

“Conjugated linoleic acid CLA ), a naturally occurring anticarcinogen found in dairy products, is an intermediary product of ruminal biohydrogenation of polyunsaturated fatty acids.”

“Evidence from animal studies suggests that conjugated linoleic acid CLA ) modulates plasma and tissue appearance of newly synthesized PUFA.”

“Supplementation with CLA or LA altered also cell membrane composition by n-6 PUFA synthesis.”

“In epididymal fat, CLA tended to decrease concentration of polyunsaturated fatty acids , the expression of SCD5 gene was upregulated by CLA 1% and CASP3 gene was upregulated by CLA 0.5%.”

“ CLA enrichment decreased the polyunsaturated and monounsaturated fatty acids and increased the saturated fatty acids in the yolk sac (P < 0.05).”

“ CLA supplementation significantly inhibited PUFA oxidation, as evidenced by the lower content of MDA in rats’ hearts, while the cancerous process intensified the oxidation of cholesterol, as confirmed by the elevated levels of 7-ketocholesterol in DMBA-treated rats.”

“Addition of CLA in the diet affected fatty acid composition in a tissue specific manner, increasing percentages of SFA in all tissues, reducing percentages of MUFA in LT and LT subcutaneous fat, and of PUFA in LT subcutaneous fat, liver and SM.”

“An increase (p < 0.05) in the concentration of pufa was observed with inclusion of DDGS, ractopamine, and CLA.”