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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Polyunsaturated Fatty Acids and Antipsychotic Agents

Research Papers that Mention the Interaction

HighlightsTelomerase level (TA) of PBMCs increased during n‐3 PUFA supplementation added to antipsychotics.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2018  |  View Paper
PUFA modified the effect of antipsychotics on triglycerides (p=0.046).
Prostaglandins, leukotrienes, and essential fatty acids  •  2012  |  View Paper
Since the EPUFA metabolism can be altered by years of untreated illness or differentially altered by various antipsychotics , the significance of EPUFA membrane status to schizophrenia psychopathophysiology is unclear.
These data indicate that lower membrane AA and DHA most likely predate the illness and probably contribute to the onset of illness, and furthermore treatment with some antipsychotics may increase the levels of EPUFAs.
Schizophrenia Research  •  2002  |  View Paper
The n-6/n-3 PUFA ratio positively correlated with severity of psychotic and depressive symptoms.
Front. Psychiatry  •  2019  |  View Paper