Possible Interaction: Polyunsaturated Fatty Acids and Aldesleukin

“The two n-3 PUFAs also inhibited the nuclear translocation of nuclear factor kappaB (NF-kappaB) and the transcription of the interleukin-2 (IL-2) gene in PMA-activated Jurkat T-cells.”

“It has been shown that a dietary increase of polyunsaturated omega 3 fatty acids reduced strongly the production of IL-1 beta, IL-2 , IL-6 and TNF-alpha (tumor necrosis factor-alpha).”

“Furthermore, IL-2 promoter activity, IL-2 and IL-13 mRNA levels, IL-2 secretion, and IL-2R α-chain expression were significantly diminished by PUFA treatment, whereas the expression of IFN-γ, IL-4, IL-10, and CD69 remained essentially unaffected by PUFAs.”

“Likewise, negative correlations between PUFAs in the diet and B-NK, IL-2 and IFN-alpha stimulated NK cell activity were found.”

“All polyunsaturated fatty acids tested caused a decrease in the concentration of interleukin-2 ; the greatest decrease (approximately 90%) was caused by eicosapentaenoate.”

“RESULTS When dietary n-6/n-3 PU A ra tio approximated 1, the lymphocyte proliferation, proportions of CD4+ and CD8+ T cell, IL- 2 an d PGE2 concentration decreased significantly.”

“In summary, we report for the first time that feeding mice a diet enriched with (n-3) PUFA reduces in vitro antigen-stimulated production of IL-2 and subsequent proliferation of naive CD4+ T lymphocytes.”