Possible Interaction: Polyphenols and Resveratrol

“These results suggest that resveratrol can inhibit platelet aggregation both in vitro and in vivo, which conceivably could be one of the mechanisms by which this red wine polyphenol exerts its cardioprotective effects.”

“In practice, diets as Mediterranean and the "French paradox" phenomenon, the light and moderate red wine consumption, supplementation with polyphenols as resveratrol or quercetin, and also experimental and clinical trials applying the mentioned have coincided in the antihypertensive effect of polyphenols , either in prevention or in therapy.”

“At lower concentrations (1 and 10 μmol/l), resveratrol increased the cell number, as did the polyphenol quercetin.”

“This variability is largely explained by geographical variations in … by the high correlations (r > 0.5) observed between urinary polyphenols and the intake … sources (e.g., resveratrol and gallic acid ethyl ester with red wine intake; caffeic, protocatechuic … with coffee consumption; and hesperetin and naringenin with citrus fruit intake).”

“It has been suggested that resveratrol could exert its protective action by acting on specific plasma membrane polyphenol binding sites (Han Y.S., et al. (2006) J Pharmacol Exp Ther 318:238–245).”

“Cotreatment of the oral tissue with dietary polyphenols , including resveratrol and quercetin, and BaP, resulted in significant inhibition of the BaP-DNA binding.”

“Very significant increase in both OTA absorption and cellular accumulation was observed upon co-incubation with certain PPs , i.e. chrysin, quercetin, genistein, biochanin A, resveratrol , at concentrations that should be encountered in the gastrointestinal tract, as well as with MK571, a specific inhibitor of MRPs efflux pumps.”

“An improved general condition is observed after treatment with RES and QRC; this explains the antioxidant and antiapoptotic effects of polyphenols.”

“This suggests that both resveratrol and resveratrol metabolites may be involved in the anti-obesity effect of this polyphenol.”

“This anti-inflammatory action of RSV likely contributes to the therapeutic effect of this plant polyphenol.”

“This effect of the polyphenol was recapitulated in vitro, where RSV (10-80 μM) robustly inhibited iNOS protein induction and NO production in cytokine/LPS-treated L6 myocytes and 3T3-L1 adipocytes.”