Possible Interaction: Polyphenols and Doxorubicin Hydrochloride

“Furthermore, TPs enhance the inhibitory effect on the growth of cancers by traditional anticancer drugs or targeted antitumor drugs in vitro and in vivo and reverse multidrug resistances of cancer cells to vincristine, doxorubicin , and 5-fluorouracil.”

“FCM results showed that the expression of Pgp was significantly decreased (32.03 +/- 2.09) After administration of GSP and ADR , there was distinct difference between it and control (55.13 +/- 2.12).”

“ TP and EGCG enhanced the DOX cytotoxicity on KB‐A‐1 cells by 5.2‐and 2.5‐times, respectively, but did not show a modulating effect on KB‐3–1 cells.”

“When 10 μg mL−1 (‐)‐epigallocatechin … (EGCG) or 40 μg mL−1 TP were present … with doxorubicin (DOX), the IC50 of DOX on KB‐A‐1 cells decreased from 10.3 ± 0.9 … mL−1 to 4.2 ± 0.2 and 2.0 ± 0.1 μg mL−1, respectively.”

“Also, there is a growing body of evidence about the combined treatment of OOPs with various anticancer drugs, such as cisplatin, tamoxifen, doxorubicin and others.”

“We first detected whether the combination of polyphenols (EGCG, tannic acid, curcumin) and doxorubicin , an anticancer drug, is synergistic or not.”

“Recently published in Nature: Cell Death and Discovery, Mahbub et al.1 have demonstrated that polyphenols can synergistically enhance the action of the topoisomerase II inhibitors: doxorubicin and etoposide in leukaemia cells.”

“ Tea polyphenol and (-)-epigallocatechin gallate enhanced the cytotoxicity of doxorubicin on KB-A-1 cells by 5.2 and 2.5 times, respectively, but did not show a modulating effect on KB-3-1 cells.”

“When 10 μg/ml (-)-epigallocatechin gallate or 40 μg/ml tea polyphenol were present simultaneously with doxorubicin , the IC50 of doxorubicin on KB-A-1 cells decreased from 10.3 ± 0.9 μg/ml to 4.2 ± 0.2 or 2.0 ± 0.1 μg/ml.”

“The results indicated that grape polyphenol concentrate was able to reduce the signs of cardiotoxicity of doxorubicin through the reduction of aspartate aminotransferase activation, increasing the plasma antioxidant levels and decreasing the level of free radicals.”