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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Polyphenols
drug:
Bortezomib
Research Papers that Mention the Interaction
“Based on these findings, restriction of the intake of natural polyphenols in foods or vitamin supplements during bortezomib treatment in MM patients should be considered.”
“However, the anticancer activity of bortezomib was blocked by the polyphenols.”
“We speculated that the vicinal diols in the polyphenols interact with the boronic acid of bortezomib and convert the active triangular boronic acid of bortezomib to an inactive tetrahedral boronate, thus abolishing the antimyeloma activity of bortezomib.”
Natural polyphenols antagonize the antimyeloma activity of proteasome inhibitor bortezomib by direct chemical interaction
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